This market will resolve to "Yes" if Kristi Noem becomes the first member of President Donald Trump's second-term cabinet to be dismissed, removed via impeachment, resign, or die. The market will resolve to "No" if any other cabinet member is dismissed, removed by the Senate after impeachment, resigns, or die before Noem, or if Noem remains in her position without such an event occurring through the end of Trump's 2nd term.

https://www.whitehouse.gov/administration/the-cabinet/

https://en.wikipedia.org/wiki/Second_cabinet_of_Donald_Trump